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Ligands
Code Name Style Show Link
MGT 7n-methyl-8-hydroguanosine-5'-triphosphate
Non-standard Residues
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Glycosylation
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Code : 5V87   PDBj   RCSB PDB   PDBe
Header : RNA BINDING PROTEIN
Title : Crystal structure of LARP1-unique domain DM15 bound to m7GpppC
Release Data : 2017-04-19
Compound :
mol_id molecule chains synonym
1 La-related protein 1 A,B La ribonucleoprotein domain family member 1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: LARP1, KIAA0731, LARP
Authors : Berman, A.J., Lahr, R.M.
Keywords : Cap-binding, RNA-binding, DM15, 5'TOP, RNA BINDING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.692 Å )
Citation :

La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.

Lahr, R.M.,Fonseca, B.D.,Ciotti, G.E.  et al.
(2017)  Elife  6

PubMed: 28379136
DOI: 10.7554/eLife.24146

Chain : A, B
UniProt : Q6PKG0 (LARP1_HUMAN)
Reaction : -