Het-PDB Navi2 (PDB: 5UIG)

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Ligands
Code	Name	Link
EDT	{[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid	PoSSuM
MES	2-(N-morpholino)-ethanesulfonic acid	PoSSuM
8D1	5-amino-N-[(2-methoxyphenyl)methyl]-2-(3-methylphenyl)-2h-1,2,3-triazole-4-carboximidamide	PoSSuM

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Download interaction data: 5UIG

Code :

5UIG PDBj RCSB PDB PDBe

Header :

ADENOSINE BINDING PROTEIN

Title :

Crystal structure of adenosine A2A receptor bound to a novel triazole-carboximidamide antagonist

Release Data :

2017-02-08

Compound :

mol_id	molecule	chains	synonym
1	Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a	A	Cytochrome b-562
	mutation: M1007W, H1102I, R1106L,M1007W, H1102I, R1106L,M1007W, H1102I, R1106L other_details: The protein is a chimera with BRIL inserted between L208 and E219

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: ADORA2A, ADORA2

Authors :

Sun, B., Bachhawat, P., Ling-Hon Chu, M., Ceska, T., Sands, Z., Lebon, F., Kobilka, T.S., Kobilka, B.

Keywords :

Adenosine, A2A receptor, GPCR, vapor diffusion, allosteric, Parkinson's disease, ADENOSINE BINDING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 3.50 Å )

Citation :

Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.

Sun, B.,Bachhawat, P.,Chu, M.L. et al.
(2017) Proc. Natl. Acad. Sci. U.S.A. 114 : 2066 - 2071

Chain :

UniProt :

P0ABE7 (C562_ECOLX)

Cofactor:	Evidence:	Note:
Reaction :	-
heme b	-	Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.

PDB ID: 5UIG