Brand  (β version)

PDB ID: 5UEU

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Ligands
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0S6 Methyl [(6s)-4-(4-chlorophenyl)-2,3,9-trimethyl-6h-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate PoSSuM
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Structure summary

Code : 5UEU   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN/INHIBITOR
Title : BRD4_BD2_A-1107604
Release Data : 2017-05-10
Compound :
mol_id molecule chains synonym
1 Bromodomain-containing protein 4 A,B Protein HUNK1
fragment: residues 352-457
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Enterobacteria phage L1  (taxid:268588)
gene: BRD4, HUNK1
Authors : Park, C.H.
Keywords : SIGNALING PROTEIN-INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 2.26 Å )
Citation :

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

Wang, L.,Pratt, J.K.,Soltwedel, T.  et al.
(2017)  J. Med. Chem.  60 : 3828 - 3850

PubMed: 28368119
DOI: 10.1021/acs.jmedchem.7b00017

Reaction

Chain : A, B
UniProt : O60885 (BRD4_HUMAN)
Reaction : -