Brand  (β version)

PDB ID: 5TWL

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Ligands
Code Name Style Show Link
H91 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-C]quinolin-2(1h)-one PoSSuM
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Structure summary

Code : 5TWL   PDBj   RCSB PDB   PDBe
Header : Transferase/Transferase Inhibitor
Title : Structure of Maternal Embryonic Leucine Zipper Kinase
Release Data : 2017-11-22
Compound :
mol_id molecule chains synonym
1 Maternal embryonic leucine zipper kinase A hMELK,Protein kinase Eg3,pEg3 kinase,Protein kinase PK38,hPK38,Tyrosine-protein kinase MELK
ec: 2.7.11.1,2.7.10.2
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: MELK, KIAA0175
Authors : Seo, H.-S., Huang, H.-T., Gray, N.S., Dhe-Paganon, S.
Keywords : kinase inhibitor, basal-like breast cancer, Transferase-Transferase Inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4200 Å )
Citation :

MELK is not necessary for the proliferation of basal-like breast cancer cells.

Huang, H.T.,Seo, H.S.,Zhang, T.  et al.
(2017)  Elife  6

PubMed: 28926338
DOI: 10.7554/eLife.26693

Reaction

Chain : A
UniProt : Q14680 (MELK_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.2 PROSITE-ProRule:PRU10027, PubMed:16216881
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ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:16216881
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:16216881
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