Brand  (β version)

PDB ID: 5TCA

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Ligands
Code Name Style Show Link
J55 1-(2-{(2s)-2-[(6-bromopyridin-2-yl)carbamoyl]-1,3-thiazolidin-3-yl}-2-oxoethyl)-1h-pyrazolo[3,4-B]pyridine-3-carboxamide PoSSuM
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Structure summary

Code : 5TCA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Complement Factor D inhibited with JH3
Release Data : 2016-10-19
Compound :
mol_id molecule chains synonym
1 Complement factor D A,B,C,D,E,F,G Adipsin,C3 convertase activator,Properdin factor D
ec: 3.4.21.46
fragment: residues 26-253
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Unidentified baculovirus  (taxid:10469)
gene: CFD, DF, PFD
Authors : Stuckey, J.A.
Keywords : serine protease, inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 3.1500 Å )
Citation :

Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors.

Yang, C.Y.,Phillips, J.G.,Stuckey, J.A.  et al.
(2016)  ACS Med Chem Lett  7 : 1092 - 1096

PubMed: 27994744
DOI: 10.1021/acsmedchemlett.6b00299

Reaction

Chain : A, B, C, D, E, F, G
UniProt : P00746 (CFAD_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. 3.4.21.46 -
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