Brand  (β version)

PDB ID: 5TAU

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Ligands
Code Name Style Show Link
ATP Adenosine-5'-triphosphate PoSSuM
CFF Caffeine PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5TAU   PDBj   RCSB PDB   PDBe
Header : TRANSPORT PROTEIN/ISOMERASE
Title : Structure of rabbit RyR1 (Caffeine/ATP/EGTA dataset, class 3)
Release Data : 2016-10-12
Compound :
mol_id molecule chains synonym
1 Peptidyl-prolyl cis-trans isomerase FKBP1B F,A,H,J PPIase FKBP1B, 12.6 kDa FK506-binding protein, FKBP-12.6, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, Calstabin 2
ec: 5.2.1.8
mol_id molecule chains synonym
2 Ryanodine receptor 1 B,I,E,G RyR1, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4
mol_id organism_scientific organism_common
2 Oryctolagus cuniculus  (taxid:9986) Rabbit
tissue: Skeletal muscle
Authors : Clarke, O.B., des Georges, A., Zalk, R., Marks, A.R., Hendrickson, W.A., Frank, J.
Keywords : RyR, Ca2+, EC coupling, gating, TRANSPORT PROTEIN-ISOMERASE complex
Exp. method : ELECTRON MICROSCOPY ( 6.2 Å )
Citation :

Structural Basis for Gating and Activation of RyR1.

des Georges, A.,Clarke, O.B.,Zalk, R.  et al.
(2016)  Cell  167 : 145 - 157.e17

PubMed: 27662087
DOI: 10.1016/j.cell.2016.08.075

Reaction

Chain : F, A, H, J
UniProt : P68106 (FKB1B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0) 5.2.1.8 PubMed:7513996, PubMed:7592869
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Chain : B, I, E, G
UniProt : P11716 (RYR1_RABIT)
Reaction: EC: Evidence:
Physiological Direction:
Ca(2+)(in) = Ca(2+)(out) - PubMed:12732639, PubMed:22036948, PubMed:26245150, PubMed:27662087
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