Brand  (β version)

PDB ID: 5QJ7

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Ligands
Code Name Style Show Link
MG Magnesium ion PoSSuM
JMM [4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone PoSSuM
EDO 1,2-ethanediol PoSSuM
CL Chloride ion PoSSuM
Non-standard Residues
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Structure summary

Code : 5QJ7   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : PanDDA analysis group deposition of models with modelled events (E.G. bound ligands) -- Crystal Structure of NUDT5 in complex with Z32327641
Release Data : 2018-12-19
Compound :
mol_id molecule chains synonym
1 ADP-sugar pyrophosphatase A,B,C,D 8-oxo-dGDP phosphatase,Nuclear ATP-synthesis protein NUDIX5,Nucleoside diphosphate-linked moiety X motif 5,hNUDT5,YSA1H
ec: 3.6.1.13,3.6.1.58,2.7.7.96
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: NUDT5, NUDIX5, HSPC115
Authors : Dubianok, Y., Collins, P., Krojer, T., Wright, N., Strain-Damerell, C., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Huber, K., von Delft, F.
Keywords : SGC - Diamond I04-1 fragment screening, PanDDA, XChemExplorer, NUDT5, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.5600 Å )
Citation :

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands)

Dubianok, Y.,Collins, P.,Krojer, T.  et al.
To Be Published 

Reaction

Chain : A, B, C, D
UniProt : Q9UKK9 (NUDT5_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + D-ribose 5-phosphate + H(+) = ADP-D-ribose + diphosphate 2.7.7.96 PubMed:27257257
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ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) 3.6.1.13 PubMed:17052728, PubMed:21389046
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8-oxo-dGDP + H2O = 8-oxo-dGMP + H(+) + phosphate 3.6.1.58 PubMed:17052728, PubMed:19699693, PubMed:21389046
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