Het-PDB Navi2 (PDB: 5QAS)

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Ligands
Code	Name		Style	Show	Link
CVF	3-[4-(2-acetamidoethyl)phenyl]benzoic acid				PoSSuM
EDO	1,2-ethanediol				PoSSuM

Non-standard Residues
Code	Name	Show
KCX	Lysine nz-carboxylic acid

Glycosylation
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Download interaction data: 5QAS

Code :

5QAS PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

OXA-48 IN COMPLEX WITH COMPOUND 23b

Release Data :

2018-01-10

Compound :

mol_id	molecule	chains
1	Beta-lactamase	A,B,C,D
	ec: 3.5.2.6

Source :

mol_id	organism_scientific	expression_system
1	Klebsiella pneumoniae (taxid:573)	Escherichia coli (taxid:562)
	gene: bla OXA-48, blaOXA-48, KPE71T_00045

Authors :

Lund, B.A., Leiros, H.K.S.

Keywords :

Oxacillinase, Inhibitor, Complex, OXA, Antibiotic resistance, beta-lactamase, fragment, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

A focused fragment library targeting the antibiotic resistance enzyme - Oxacillinase-48: Synthesis, structural evaluation and inhibitor design.

Akhter, S.,Lund, B.A.,Ismael, A. et al.
(2018) Eur J Med Chem 145 : 634 - 648

Chain :

A, B, C, D

UniProt :

Q6XEC0 (BLO48_KLEPN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PubMed:14693513, PubMed:19477418, PubMed:27073009, PubMed:38161376
a beta-lactam + H2O = a substituted beta-amino acid	-

PDB ID: 5QAS