Brand  (β version)

PDB ID: 5PB4

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Ligands
Code Name Style Show Link
9RS N-({3-[5-hydroxy-3-methyl-4-(1h-pyrrolo[3,2-C]pyridin-2-yl)-1h-pyrazol-1-yl]phenyl}methyl)-N'-phenylurea PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
SO4 Sulfate ion PoSSuM
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Structure summary

Code : 5PB4   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : human factor VIIa in complex with 1-[[3-[5-hydroxy-3-methyl-4-(1H-pyrrolo[3,2-C]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylurea at 2.43A
Release Data : 2017-06-21
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII light chain A Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
mol_id molecule chains synonym
2 Coagulation factor VII heavy chain C Proconvertin,Serum prothrombin conversion accelerator,SPCA
ec: 3.4.21.21
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: F7
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: F7
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
Authors : Stihle, M., Mayweg, A., Roever, S., Rudolph, M.G.
Keywords : GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM-BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.4300 Å )
Citation :

Crystal Structure of a Factor VIIa complex

Mayweg, A.,Roever, S.,Rudolph, M.G.
To be published 

Reaction

Chain : C
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
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