Brand  (β version)

PDB ID: 5OO3

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Ligands
Code Name Style Show Link
9ZB 1-(4-ethyl-2,3-dihydroquinoxalin-1-yl)propan-1-one PoSSuM
Non-standard Residues
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Glycosylation
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Modification
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Structure summary

Code : 5OO3   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Cdk2(F80C, C177A) with covalent ligand at F80C
Release Data : 2018-08-29
Compound :
mol_id molecule chains synonym
1 Cyclin-dependent kinase 2 A Cell division protein kinase 2,p33 protein kinase
ec: 2.7.11.22
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CDK2, CDKN2
Authors : Craven, G., Morgan, R.M.L., Mann, D.J.
Keywords : Covalent inhibitor, Cysteine modification, Kinase, Allosteric inhibitor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.73 Å )
Citation :

High-throughput kinetic analysis for target-directed covalent ligand discovery

Craven, G.,Affron, D.P.,Allen, C.E.  et al.
To Be Published 

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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