Het-PDB Navi2 (PDB: 5ONE)

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Ligands
Code	Name		Style	Show	Link
9YQ	4-(propanoylamino)-~{N}-[4-[(5,8,11-trimethyl-6-oxidanylidene-pyrimido[4,5-B][1,4]benzodiazepin-2-yl)amino]phenyl]benzamide				PoSSuM

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Download interaction data: 5ONE

Code :

5ONE PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal structure of Aurora-A in complex with FMF-03-145-1 (compound 2)

Release Data :

2017-09-06

Compound :

mol_id	molecule	chains	synonym
1	Aurora kinase A	A	Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A
	ec: 2.7.11.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6 expression_system_strain: BL21(DE3) expression_system_variant: R3-pRARE2 expression_system_vector_type: plasmid

Authors :

Chaikuad, A., Ferguson, F.M., Gray, N.S., Knapp, S.

Keywords :

aurora kinase, kinase, inhibitor complex, cell cycle, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.60 Å )

Citation :

Characterization of a highly selective inhibitor of the Aurora kinases.

Ferguson, F.M.,Doctor, Z.M.,Chaikuad, A. et al.
(2017) Bioorg. Med. Chem. Lett. 27 : 4405 - 4408

Chain :

UniProt :

O14965 (AURKA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27192185, PubMed:27837025, PubMed:28218735
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.1	PubMed:12237287, PubMed:16337122, PubMed:19140666, PubMed:19402633, PubMed:27837025, PubMed:28218735
	-

PDB ID: 5ONE