Brand  (β version)

PDB ID: 5OKT

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Ligands
Code Name Style Show Link
9XK ~{N}-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxidanylidene-3-phenyl-6,7-dihydrothieno[3,2-D]pyrimidin-2-yl)sulfanyl]ethanamide PoSSuM
SO4 Sulfate ion PoSSuM
ACT Acetate ion PoSSuM
Non-standard Residues
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TPO Phosphothreonine
Glycosylation
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Modification
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Structure summary

Code : 5OKT   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of human Casein Kinase I delta in complex with IWP-2
Release Data : 2018-04-25
Compound :
mol_id molecule chains synonym
1 Casein kinase I isoform delta A,B CKId,Tau-protein kinase CSNK1D
ec: 2.7.11.1,2.7.11.26
mol_id molecule chains synonym
2 Casein kinase I isoform delta C,D CKId,Tau-protein kinase CSNK1D
ec: 2.7.11.1,2.7.11.26
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CSNK1D, HCKID
expression_system_variant: TAKARA 2
expression_system_vector_type: Plasmid
expression_system_vector: pET28a
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CSNK1D, HCKID
expression_system_variant: TAKARA 2
expression_system_vector_type: Plasmid
expression_system_vector: pET28a
Authors : Pichlo, C., Brunstein, E., Baumann, U.
Keywords : CK1D, Kinase-inhibitor complex, transferase, Kinase
Exp. method : X-RAY DIFFRACTION ( 2.130 Å )
Citation :

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) delta / epsilon.

Garcia-Reyes, B.,Witt, L.,Jansen, B.  et al.
(2018)  J. Med. Chem.  61 : 4087 - 4102

PubMed: 29630366
DOI: 10.1021/acs.jmedchem.8b00095

Reaction

Chain : C, D
UniProt : P48730 (KC1D_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:12270943, PubMed:14761950, PubMed:16618118, PubMed:17562708, PubMed:17962809, PubMed:19043076, PubMed:19591487, PubMed:20041275, PubMed:20048001, PubMed:20637175, PubMed:20699359, PubMed:21084295, PubMed:21422228, PubMed:23636092
left-to-right PubMed:20637175
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:10606744, PubMed:14761950, PubMed:17562708, PubMed:19591487, PubMed:20041275, PubMed:20637175, PubMed:21422228, PubMed:23636092
left-to-right PubMed:20637175
ATP + L-seryl-[tau protein] = ADP + H(+) + O-phospho-L-seryl- [tau protein] 2.7.11.26 PubMed:14761950, PubMed:16618118, PubMed:17562708
left-to-right PubMed:14761950
ATP + L-threonyl-[tau protein] = ADP + H(+) + O-phospho-L- threonyl-[tau protein] 2.7.11.26 PubMed:14761950, PubMed:16618118, PubMed:17562708
left-to-right PubMed:14761950