Brand  (β version)

PDB ID: 5OJN

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Ligands
Code Name Style Show Link
9X8 Thioacetyl-ADP-ribose PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5OJN   PDBj   RCSB PDB   PDBe
Header : SIGNALING PROTEIN
Title : Sirtuin 4 from Xenopus tropicalis in complex with thioacetyl-ADP-ribose
Release Data : 2017-11-29
Compound :
mol_id molecule chains synonym
1 NAD-dependent protein deacylase A Sirtuin 4, Regulatory protein SIR2 homolog
ec: 3.5.1.-
Source :
mol_id organism_scientific organism_common expression_system
1 Xenopus tropicalis  (taxid:8364) Western clawed frog Escherichia coli  (taxid:562)
gene: sirt4, TGas015j14.1-001
Authors : Pannek, M., Steegborn, C.
Keywords : Sirtuin, Sirt4, Deacylase, Mitochondria, SIGNALING PROTEIN
Exp. method : X-RAY DIFFRACTION ( 1.80 Å )
Citation :

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.

Pannek, M.,Simic, Z.,Fuszard, M.  et al.
(2017)  Nat Commun  8 : 1513 - 1513

PubMed: 29138502
DOI: 10.1038/s41467-017-01701-2

Reaction

Chain : A
UniProt : Q28CB4 (Q28CB4_XENTR)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl- ADP-D-ribose + L-lysyl-[protein] + nicotinamide 2.3.1.286 HAMAP-Rule:MF_03161
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