Het-PDB Navi2 (PDB: 5OI5)

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Ligands
Code	Name		Style	Show	Link
9VK	(2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid				PoSSuM
MG	Magnesium ion				PoSSuM

Non-standard Residues
Code	Name	Show
CAS	S-(dimethylarsenic)cysteine

Glycosylation
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Download interaction data: 5OI5

Code :

5OI5 PDBj RCSB PDB PDBe

Header :

VIRAL PROTEIN

Title :

Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1

Release Data :

2018-03-07

Compound :

mol_id	molecule	chains
1	Integrase	A
	fragment: Catalytic core domain, UNP Residues 50-212

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Human immunodeficiency virus 1 (taxid:11676)	HIV-1	Escherichia coli (taxid:562)

Authors :

Ruff, M., Benarous, R.

Keywords :

HIV-1, Integrase, Catalytic core domain, VIRAL PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.40 Å )

Citation :

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.

Bonnard, D.,Le Rouzic, E.,Eiler, S. et al.
(2018) J. Biol. Chem. 293 : 6172 - 6186

PDB ID: 5OI5