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Ligands
Code Name Style Show Link
9NQ Leniolisib
Non-standard Residues
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Glycosylation
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Code : 5O83   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Discovery of CDZ173 (leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
Release Data : 2017-09-20
Compound :
mol_id molecule chains synonym
1 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform A PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta
ec: 2.7.1.153
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Spodoptera frugiperda  (taxid:7108)
gene: Pik3cd
expression_system_common: Fall armyworm
expression_system_strain: Sf9-DE
Authors : Gutmann, S., Rummel, G., Shrestha, B.
Keywords : kinase, transferase, PI3K delta, inhibitor
Exp. method : X-RAY DIFFRACTION ( 2.90 Å )
Citation :

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.

Hoegenauer, K.,Soldermann, N.,Zecri, F.  et al.
(2017)  ACS Med Chem Lett  8 : 975 - 980

PubMed: 28947947
DOI: 10.1021/acsmedchemlett.7b00293

Chain : A
UniProt : O35904 (PK3CD_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5- bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol-3,4,5-trisphosphate) + ADP + H(+) 2.7.1.153 UniProtKB:O00329
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+) 2.7.1.137 UniProtKB:O00329
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1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero- 3-phospho-1D-myo-inositol 4,5-bisphosphate + ATP = 1-octadecanoyl-2- (5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo- inositol 3,4,5-triphosphate) + ADP + H(+) - UniProtKB:O00329
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