Brand  (β version)

PDB ID: 5O7N

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
9NK (2~{R})-1-[(2~{S})-2-(phenylmethyl)-3-sulfanyl-propanoyl]piperidine-2-carboxylic acid PoSSuM
FMT Formic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Structure summary

Code : 5O7N   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Beta-lactamase VIM-2 in complex with (2R)-1-(2-Benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid
Release Data : 2018-06-20
Compound :
mol_id molecule chains
1 Beta-lactamase VIM-2 A,B
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli BL21(DE3)  (taxid:469008)
gene: blaVIM-2
expression_system_vector_type: plasmid
expression_system_plasmid: pdest14
Authors : Buettner, D., Kramer, J.S., Pogoryelov, D., Proschak, E.
Keywords : Inhibitor, Complex, MBL, Beta-lactamase VIM-2, (2R)-1-(2-Benzyl-3-mercaptopropanoyl)piperidine-2-carboxylic acid, Hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.5000 Å )
Citation :

Challenges in the Development of a Thiol-Based Broad-Spectrum Inhibitor for Metallo-beta-Lactamases.

Buttner, D.,Kramer, J.S.,Klingler, F.M.  et al.
(2018)  Acs Infect Dis.  4 : 360 - 372

PubMed: 29172434
DOI: 10.1021/acsinfecdis.7b00129

Reaction

Chain : A, B
UniProt : A0A173FE28 (A0A173FE28_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 ARBA:ARBA00001526
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Cofactor: Evidence: Note:
Zn(2+) ECO:0000256 | ARBA:ARBA00001947
-