Het-PDB Navi2 (PDB: 5O1A)

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Ligands
Code	Name		Style	Show	Link
ZN	Zinc ion				PoSSuM
9H5	[3,5-bis(iodanyl)-2-oxidanyl-4-pyrrol-1-yl-phenyl]-(4-methylpiperazin-1-yl)methanone				PoSSuM

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Download interaction data: 5O1A

Code :

5O1A PDBj RCSB PDB PDBe

Header :

DNA BINDING PROTEIN

Title :

p53 cancer mutant Y220C in complex with compound MB240

Release Data :

2018-05-09

Compound :

mol_id	molecule	chains	synonym
1	Cellular tumor antigen p53	A,B	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
	fragment: UNP residues 94-312 mutation: M133L, V203A, Y220C, N239Y, N268D other_details: DNA-binding domain

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: TP53, P53

Authors :

Joerger, A.C., Bauer, M.R., Baud, M.G.J., Fersht, A.R.

Keywords :

p53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, DNA binding protein, molecular chaperones

Exp. method :

X-RAY DIFFRACTION ( 1.440 Å )

Citation :

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.

Baud, M.G.J.,Bauer, M.R.,Verduci, L. et al.
(2018) Eur J Med Chem 152 : 101 - 114

PDB ID: 5O1A