Brand  (β version)

PDB ID: 5O13

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Ligands
Code Name Style Show Link
9G5 (3~{E})-5-chloranyl-3-[[5-[3-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl]furan-2-yl]methylidene]-1~{H}-indol-2-one PoSSuM
CL Chloride ion PoSSuM
IMD Imidazole PoSSuM
Non-standard Residues
Code Name Show
CSX S-oxy cysteine
SEP Phosphoserine
Glycosylation
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Structure summary

Code : 5O13   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of PIM1 kinase in complex with small-molecule inhibitor
Release Data : 2017-11-01
Compound :
mol_id molecule chains
1 Serine/threonine-protein kinase pim-1 A
ec: 2.7.11.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PIM1
Authors : Dubin, G., Bogusz, J.
Keywords : kinase, PIM1, CX-6258, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.44 Å )
Citation :

Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.

Bogusz, J.,Zrubek, K.,Rembacz, K.P.  et al.
(2017)  Sci Rep  7 : 13399 - 13399

PubMed: 29042609
DOI: 10.1038/s41598-017-13557-z

Reaction

Chain : A
UniProt : P11309 (PIM1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862, PubMed:31548394
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.1 PubMed:15525646, PubMed:15657054, PubMed:15808862
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