Brand  (β version)

PDB ID: 5O0B

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Ligands
Code Name Style Show Link
9FE 3-bromanyl-1~{H}-indazole-5-carboxylic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5O0B   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of Phosphopantetheine adenylyltransferase from Mycobacterium abcessus in complex with 3-Bromo-1H-indazole-5-carboxylic acid (Fragment 2)
Release Data : 2017-06-28
Compound :
mol_id molecule chains synonym
1 Phosphopantetheine adenylyltransferase A,B,C Dephospho-CoA pyrophosphorylase,Pantetheine-phosphate adenylyltransferase,PPAT
ec: 2.7.7.3
Source :
mol_id organism_scientific expression_system
1 Mycobacterium abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)  (taxid:561007) Escherichia coli BL21(DE3)  (taxid:469008)
gene: coaD, MAB_3259c
Authors : Thomas, S.E., Kim, S.Y., Mendes, V., Blaszczyk, M., Blundell, T.L.
Keywords : Coenzyme A Biosynthesis, Transferase
Exp. method : X-RAY DIFFRACTION ( 1.7350 Å )
Citation :

Structural Biology and the Design of New Therapeutics: From HIV and Cancer to Mycobacterial Infections: A Paper Dedicated to John Kendrew.

Thomas, S.E.,Mendes, V.,Kim, S.Y.  et al.
(2017)  J. Mol. Biol.  429 : 2677 - 2693

PubMed: 28648615
DOI: 10.1016/j.jmb.2017.06.014

Reaction

Chain : A, B, C
UniProt : B1MDL6 (COAD_MYCA9)
Reaction: EC: Evidence:
Physiological Direction:
(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate 2.7.7.3 HAMAP- Rule:MF_00151
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