Brand  (β version)

PDB ID: 5NZM

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Ligands
Code Name Style Show Link
9ET Murrayamine-I PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5NZM   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of UDP-glucose pyrophosphorylase from Leishmania major in complex with murrayamine-I
Release Data : 2018-04-18
Compound :
mol_id molecule chains
1 UDP-glucose pyrophosphorylase A
ec: 2.7.7.9
Source :
mol_id organism_scientific expression_system
1 Leishmania major  (taxid:5664) Escherichia coli  (taxid:562)
gene: UGP, LMJF_18_0990
Authors : Cramer, J.T., Fuehring, J.I., Baruch, P., Bruetting, C., Hesse, R., Knoelker, H.-J., Gerardy-Schahn, R., Fedorov, R.
Keywords : NTP-transferase, Pathogen, Allostery, Catalysis, transferase
Exp. method : X-RAY DIFFRACTION ( 2.35 Å )
Citation :

Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies

Cramer, J.T.,Fuehring, J.I.,Baruch, P.  et al.
(2018)  Acs Catalysis  8

DOI: 10.1021/acscatal.7b03714

Reaction

Chain : A
UniProt : Q4QDU3 (Q4QDU3_LEIMA)
Reaction: EC: Evidence:
Physiological Direction:
alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP- alpha-D-glucose 2.7.7.9 PIRNR:PIRNR000806
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