Het-PDB Navi2 (PDB: 5NYH)

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Ligands
Code	Name		Style	Show	Link
9EK	~{N}-methyl-~{N}-(4-morpholin-4-ylphenyl)-6-oxidanyl-3-pyrrolidin-1-ylcarbonyl-2~{H}-indazole-5-carboxamide				PoSSuM

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Download interaction data: 5NYH

Code :

5NYH PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

Crystal Structure of Hsp90-alpha N-Domain in complex with Indazole derivative

Release Data :

2018-04-18

Compound :

mol_id	molecule	chains	synonym
1	Heat shock protein HSP 90-alpha	A	Heat shock 86 kDa,HSP86,Lipopolysaccharide-associated protein 2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HSP90AA1, HSP90A, HSPC1, HSPCA

Authors :

Amaral, M.

Keywords :

CHAPERONE

Exp. method :

X-RAY DIFFRACTION ( 1.65 Å )

Citation :

Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.

Schuetz, D.A.,Richter, L.,Amaral, M. et al.
(2018) J. Med. Chem. 61 : 4397 - 4411

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 5NYH