Brand  (β version)

PDB ID: 5NX5

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Ligands
Code Name Style Show Link
0FV (2z)-2-fluoro-3,7-dimethylocta-2,6-dien-1-yl trihydrogen diphosphate PoSSuM
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5NX5   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Crystal structure of Linalool/Nerolidol synthase from Streptomyces clavuligerus in complex with 2-fluorogeranyl diphosphate
Release Data : 2017-09-20
Compound :
mol_id molecule chains synonym
1 Pentalenene synthase A,B Linalool/Nerolidol synthase
ec: 4.2.3.7
Source :
mol_id organism_scientific expression_system
1 Streptomyces clavuligerus  (taxid:1901) Escherichia coli  (taxid:562)
gene: SCLAV_p1185
Authors : Karuppiah, V., Leys, D., Scrutton, N.S.
Keywords : terpene synthase, linalool, nerolidol, monoterpenoid, ligase
Exp. method : X-RAY DIFFRACTION ( 1.820 Å )
Citation :

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.

Karuppiah, V.,Ranaghan, K.E.,Leferink, N.G.H.  et al.
(2017)  ACS Catal  7 : 6268 - 6282

PubMed: 28966840
DOI: 10.1021/acscatal.7b01924

Reaction

Chain : A, B
UniProt : D5SL78 (LNSA_STRCL)
Reaction: EC: Evidence:
Physiological Direction:
(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate 4.2.3.26 PubMed:28966840
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(2E,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate - PubMed:28966840
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