Brand  (β version)

PDB ID: 5NX2

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Ligands
Code Name Style Show Link
SOG Octyl 1-thio-beta-D-glucopyranoside PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
9DK 3-[2-(1~{H}-imidazol-4-yl)ethylamino]-2,2-dimethyl-3-oxidanylidene-propanoic acid
9DQ (2~{S})-2-azanyl-3-(1~{H}-1,2,3,4-tetrazol-5-yl)propanoic acid
9DT (2~{S})-2-azanyl-3-(2-fluorophenyl)-2-methyl-propanoic acid
9DW (2~{S})-2-azanyl-3-[4-(2-ethyl-4-methoxy-phenyl)phenyl]propanoic acid
9DZ (2~{S})-2-azanyl-5-(3,5-dimethylphenyl)pentanamide

Structure summary

Code : 5NX2   PDBj   RCSB PDB   PDBe
Header : MEMBRANE PROTEIN
Title : Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution
Release Data : 2017-06-14
Compound :
mol_id molecule chains synonym
1 Glucagon-like peptide 1 receptor A GLP-1R
fragment: UNP residues 24-432
mutation: T207E, Q211A, D215R, L232F, G295A, T298A, C329A, P358A, G361A, H363V, V405A
mol_id molecule chains
2 truncated peptide agonist B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: GLP1R
expression_system_common: Fall armyworm
expression_system_vector_type: Baculovirus
expression_system_plasmid: pFastBac1-HM
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Rappas, M., Jazayeri, A., Brown, A.J.H., Kean, J., Errey, J.C., Robertson, N., Fiez-Vandal, C., Andrews, S.P., Congreve, M., Bortolato, A., Mason, J.S., Baig, A.H., Teobald, I., Dore, A.S., Weir, M., Cooke, R.M., Marshall, F.H.
Keywords : 7TM, GPCR, signalling protein, membrane protein
Exp. method : X-RAY DIFFRACTION ( 3.700 Å )
Citation :

Crystal structure of the GLP-1 receptor bound to a peptide agonist.

Jazayeri, A.,Rappas, M.,Brown, A.J.H.  et al.
(2017)  Nature  546 : 254 - 258

PubMed: 28562585
DOI: 10.1038/nature22800

Reaction

Chain : A
UniProt : P43220 (GLP1R_HUMAN)
Reaction : -