Brand  (β version)

PDB ID: 5NVH

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Ligands
Code Name Style Show Link
SO4 Sulfate ion PoSSuM
ZN Zinc ion PoSSuM
9B2 2-(4-piperidin-1-ylphenyl)-3~{H}-quinazolin-4-one PoSSuM
GOL Glycerol PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5NVH   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of TNKS2 in complex with 2-[4-(piperidin-1-yl)phenyl]-3,4-dihydroquinazolin-4-one
Release Data : 2018-03-14
Compound :
mol_id molecule chains synonym
1 Tankyrase-2 A,B TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
fragment: UNP residues 946-1113
mol_id molecule chains synonym
2 Tankyrase-2 I,J TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein
ec: 2.4.2.30
fragment: UNP residues 1114-1162
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_variant: Rosetta2
expression_system_vector_type: Plasmid
expression_system_plasmid: PNIC-BSA4
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: TNKS2, PARP5B, TANK2, TNKL
expression_system_variant: Rosetta2
expression_system_vector_type: Plasmid
expression_system_plasmid: PNIC-BSA4
Authors : Nkizinkiko, Y., Haikarainen, T., Lehtio, L.
Keywords : Tankyrase, Inhibitor, ARTD6, PARP5b, ADP-ribosyltransferase, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.

Nkizinkiko, Y.,Desantis, J.,Koivunen, J.  et al.
(2018)  Sci Rep  8 : 1680 - 1680

PubMed: 29374194
DOI: 10.1038/s41598-018-19872-3

Reaction

Chain : I, J
UniProt : Q9H2K2 (TNKS2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H(+). 2.4.2.30 PubMed:19759537, PubMed:21478859
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L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L- aspartyl-[protein] + nicotinamide - ECO:0000305
left-to-right
L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L- glutamyl-[protein] + nicotinamide - ECO:0000305
left-to-right