Brand  (β version)

PDB ID: 5NRS

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Ligands
Code Name Style Show Link
962 (2~{S})-1-[2-hydroxyethyl-[(2~{S})-2-oxidanylpropyl]amino]propan-2-ol PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5NRS   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human DNMT3B PWWP domain in complex with N,N-bis(2-hydroxypropyl)ethanolamine
Release Data : 2018-05-30
Compound :
mol_id molecule chains synonym
1 DNA (cytosine-5)-methyltransferase 3B A,B Dnmt3b,DNA methyltransferase HsaIIIB,M.HsaIIIB
ec: 2.1.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: DNMT3B
expression_system_vector_type: PLASMID
expression_system_plasmid: pET28-MHL
Authors : Rondelet, G., Wouters, J.
Keywords : DNMT3B PWWP DOMAIN, HISTONE BINDING, BETA BARREL, LIGAND, transferase
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Targeting PWWP domain of DNA methyltransferase 3B for epigenetic cancer therapy: Identification and structural characterization of new potential protein-protein interaction inhibitors

Rondelet, G.,Dal Maso, T.,Maniquet, A.  et al.
To be published 

Reaction

Chain : A, B
UniProt : Q9UBC3 (DNM3B_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5- methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine 2.1.1.37 PROSITE-ProRule:PRU10018
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