Het-PDB Navi2 (PDB: 5NOV)

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Ligands
Code	Name		Style	Show	Link
93B	1,3-diazinane-2-thione				PoSSuM

Non-standard Residues
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Glycosylation
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Modification
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Download interaction data: 5NOV

Code :

5NOV PDBj RCSB PDB PDBe

Header :

ISOMERASE

Title :

Structure of cyclophilin A in complex with hexahydropyrimidine-2-thione

Release Data :

2017-07-12

Compound :

mol_id	molecule	chains	synonym
1	Peptidyl-prolyl cis-trans isomerase A	A	PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A
	ec: 5.2.1.8

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: PPIA, CYPA

Authors :

Georgiou, C., Mcnae, I.W., Ioannidis, H., Julien, M., Walkinshaw, M.D.

Keywords :

LIGAND COMPLEX, BETA BARREL, PROLYL CIS/TRANS ISOMERASE, CYTOSOLIC, isomerase

Exp. method :

X-RAY DIFFRACTION ( 2.00 Å )

Citation :

Pushing the Limits of Detection of Weak Binding Using Fragment-Based Drug Discovery: Identification of New Cyclophilin Binders.

Georgiou, C.,McNae, I.,Wear, M. et al.
(2017) J. Mol. Biol. 429 : 2556 - 2570

Chain :

UniProt :

P62937 (PPIA_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0)	5.2.1.8	PubMed:2001362, PubMed:20676357, PubMed:21245143, PubMed:21593166, PubMed:25678563, PubMed:19207730, PubMed:26095851
	-

PDB ID: 5NOV