Brand  (β version)

color scheme of protein:

hetatm:

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information
centroid:
interaction residue:

chain: Hide other chain(s)

Ligands
Code Name Link
9CW (1~{R},3~{S},5~{z})-5-[(2~{E})-2-[(1~{R},3~{a}~{S},7~{a}~{R})-7~{a}-methyl-1-[(1~{S})-1-[(2~{S},5~{S})-5-(2-oxidanylpropan-2-yl)oxolan-2-yl]ethyl]-2,3,3~{a},5,6,7-hexahydro-1~{H}-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
Code : 5NMA
Header : TRANSCRIPTION
Title : Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain
Release Data : 2017-05-24
Compound :
mol_id molecule chains synonym
1 Vitamin D3 receptor A A VDR-A,1,25-dihydroxyvitamin D3 receptor A,Nuclear receptor subfamily 1 group I member 1-A
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1 B NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1
ec: 2.3.1.48
fragment: UNP residues 686-700
Source :
mol_id organism_scientific organism_common expression_system
1 Danio rerio  (taxid:7955) Zebrafish Escherichia coli  (taxid:562)
gene: vdra, nr1i1a, vdr
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
synthetic: yes
Authors : Rochel, N., Belorusova, A.Y.
Keywords : vitamin D nuclear receptor, transcription
Exp. method : X-RAY DIFFRACTION ( 2.800 Å )
Citation :

Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.

Belorusova, A.Y.,Martinez, A.,Gandara, Z.  et al.
(2017)  Eur J Med Chem  134 : 86 - 96

PubMed: 28399453
DOI: 10.1016/j.ejmech.2017.03.081

Chain : A
UniProt : Q9PTN2 (VDRA_DANRE)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction : Acetyl-CoA + [histone] = CoA + acetyl- [histone].