Het-PDB Navi2 (PDB: 5NKE)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
90B	2-[[3-bromanyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{N}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5NKE

Code :

5NKE PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with Compound 3a

Release Data :

2017-06-07

Compound :

mol_id	molecule	chains	synonym
1	Ephrin type-A receptor 2	A	Epithelial cell kinase,Tyrosine-protein kinase receptor ECK
	ec: 2.7.10.1 fragment: UNP residues 596-900

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: EPHA2, ECK expression_system_common: Fall armyworm

Authors :

Kudlinzki, D., Linhard, V.L., Witt, K., Gande, S.L., Saxena, K., Heinzlmeir, S., Medard, G., Kuester, B., Schwalbe, H.

Keywords :

Inhibitor, Complex, Protein Tyrosine Kinase, transferase

Exp. method :

X-RAY DIFFRACTION ( 1.39 Å )

Citation :

Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.

Heinzlmeir, S.,Lohse, J.,Treiber, T. et al.
(2017) ChemMedChem 12 : 999 - 1011

Chain :

UniProt :

P29317 (EPHA2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:2174105
	-	PROSITE-ProRule:PRU10028, PubMed:2174105

PDB ID: 5NKE