Brand  (β version)

color scheme of protein:

hetatm:

x
information
centroid:
interaction residue:

chain:

Ligands
Code Name Link
YB Ytterbium (III) ion
ZN Zinc ion
DJ3 5s-5,6-oxido-7,9-trans-11,14-cis-eicosatetraenoic acid
Code : 5NI2
Header : HYDROLASE
Title : Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form I)
Release Data : 2017-08-23
Compound :
mol_id molecule chains synonym
1 Leukotriene A-4 hydrolase A LTA-4 hydrolase,Leukotriene A(4) hydrolase
ec: 3.3.2.6
mutation: E271A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: LTA4H, LTA4
expression_system_strain: JM101
expression_system_vector_type: plasmid
expression_system_plasmid: pT3MB4
Authors : Stsiapanava, A.
Keywords : Metallopeptidase, epoxide hydrolase, leukotriene A4, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.501 Å )
Citation :

Capturing LTA4 hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB4 synthesis.

Stsiapanava, A.,Samuelsson, B.,Haeggstrom, J.Z.
(2017)  Proc. Natl. Acad. Sci. U.S.A.  114 : 9689 - 9694

PubMed: 28827365
DOI: 10.1073/pnas.1710850114

Chain : A
UniProt : P09960 (LKHA4_HUMAN)
Reaction : (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.