Brand  (β version)

PDB ID: 5N7B

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Ligands
Code Name Style Show Link
EDO 1,2-ethanediol PoSSuM
A2G 2-acetamido-2-deoxy-alpha-D-galactopyranose PoSSuM
Non-standard Residues
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CG6 Beta-methyl-cysteine
Glycosylation
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NH2 Amino group

Structure summary

Code : 5N7B   PDBj   RCSB PDB   PDBe
Header : IMMUNE SYSTEM
Title : Understanding the singular conformational landscape of the Tn antigens: Sulfur-for- oxygen substitution in the glycosidic linkage provides new insights into molecular recognition by an antibody
Release Data : 2018-06-27
Compound :
mol_id molecule chains
1 Ig heavy chain V-III region J606,Ig lambda-1 chain V region S43 H
other_details: Please follow the numbering described in the PDB entry 5A2K
mol_id molecule chains
2 APD(CG6)RP(NH2) peptide I
Source :
mol_id organism_scientific organism_common expression_system
1 Mus musculus  (taxid:10090) Mouse Komagataella phaffii GS115  (taxid:644223)
expression_system_vector_type: Plasmid
expression_system_plasmid: pPICZalphaA
mol_id organism_scientific
2 Synthetic construct  (taxid:32630)
synthetic: yes
Authors : Companon, I., Martinez-Saez, N., Castro-Lopez, J., Jimenez-Barbero, J., Bernardes, G.J.L., Busto, J.H., Avenoza, A., Jimenez-Oses, G., Hurtado-Guerrero, R., Peregrina, J.M., Corzana, F.
Keywords : IMMUNE SYSTEM, ANTIBODIES, ANTIGEN Tn
Exp. method : X-RAY DIFFRACTION ( 1.70 Å )
Citation :

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.

Companon, I.,Guerreiro, A.,Mangini, V.  et al.
(2019)  J.Am.Chem.Soc.  141 : 4063 - 4072

PubMed: 30726084
DOI: 10.1021/jacs.8b13503

Reaction

Chain : H
UniProt : P01801 (HVM32_MOUSE)
Reaction : -
Chain : H
UniProt : P01727 (LV1E_MOUSE)
Reaction : -