Brand  (β version)

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Ligands
Code Name Link
CL Chloride ion
FAD Flavin-adenine dinucleotide
FYK 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid
GOL Glycerol
Code : 5MZI
Header : OXIDOREDUCTASE
Title : Pseudomonas fluorescens kynurenine 3-monooxygenase (KMO) in complex with 3-(5-chloro-6-cyclopropoxy-2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)propanoic acid
Release Data : 2017-04-19
Compound :
mol_id molecule chains synonym
1 Kynurenine 3-monooxygenase A,B PfKMO,Kynurenine 3-hydroxylase
ec: 1.14.13.9
mutation: C252S C461S
Source :
mol_id organism_scientific expression_system
1 Pseudomonas fluorescens  (taxid:294) Escherichia coli  (taxid:562)
gene: kmo, qbsG
Authors : Rowland, P.
Keywords : KMO, Oxidoreductase
Exp. method : X-RAY DIFFRACTION ( 1.71 Å )
Citation :

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Walker, A.L.,Ancellin, N.,Beaufils, B.  et al.
(2017)  J. Med. Chem.  60 : 3383 - 3404

PubMed: 28398044
DOI: 10.1021/acs.jmedchem.7b00055

Chain : A, B
UniProt : Q84HF5 (KMO_PSEFL)
Reaction : L-kynurenine + NADPH + O(2) = 3-hydroxy-L- kynurenine + NADP(+) + H(2)O.