PDB ID: 5MKZ
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Structure summary
Code : | 5MKZ PDBj RCSB PDB PDBe | ||||||||||||
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Header : | TRANSCRIPTION | ||||||||||||
Title : | N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 4-chloro-2-methyl-5-(((3-methylthiophen-2-yl)methyl)amino)pyridazin-3(2H)-one | ||||||||||||
Release Data : | 2017-12-20 | ||||||||||||
Compound : |
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Source : |
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Authors : | Chung, C.-W. | ||||||||||||
Keywords : | INHIBITOR, HISTONE, EPIGENETIC READER, BROMODOMAIN, BRD4, BROMODOMAIN CONTAINING PROTEIN 4, ANTAGONIST, TRANSCRIPTION | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.62 Å ) | ||||||||||||
Citation : |
Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.
Humphreys, P.G.,Bamborough, P.,Chung, C.W.
et al.
PubMed: 28002667 |
Reaction
Chain : | A |
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UniProt : | O60885 (BRD4_HUMAN) |
Reaction : | - |