PDB ID: 5M8G
Hetero Atom Contents
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Code | Name | Style | Show | Link | |
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918 | 5-(2-morpholin-4-yl-6-pyrrolidin-1-yl-pyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine | PoSSuM | |||
ACP | Phosphomethylphosphonic acid adenylate ester | PoSSuM | |||
CA | Calcium ion | PoSSuM | |||
GDP | Guanosine-5'-diphosphate | PoSSuM | |||
GOL | Glycerol | PoSSuM | |||
GTP | Guanosine-5'-triphosphate | PoSSuM | |||
MES | 2-(N-morpholino)-ethanesulfonic acid | PoSSuM | |||
MG | Magnesium ion | PoSSuM |
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Download interaction data: 5M8G
Structure summary
Code : | 5M8G PDBj RCSB PDB PDBe | ||||||||||||||||||||||||||||||||||||||||||||||||
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Header : | CELL CYCLE | ||||||||||||||||||||||||||||||||||||||||||||||||
Title : | Tubulin-MTD265 complex | ||||||||||||||||||||||||||||||||||||||||||||||||
Release Data : | 2017-02-22 | ||||||||||||||||||||||||||||||||||||||||||||||||
Compound : |
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Source : |
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Authors : | Bohnacker, T., Prota, A.E., Steinmetz, M.O., Wymann, M.P. | ||||||||||||||||||||||||||||||||||||||||||||||||
Keywords : | CELL CYCLE, TUBULIN FOLD, CYTOSKELETON, MICROTUBULE | ||||||||||||||||||||||||||||||||||||||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 2.147 Å ) | ||||||||||||||||||||||||||||||||||||||||||||||||
Citation : |
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Bohnacker, T.,Prota, A.E.,Beaufils, F.
et al.
PubMed: 28276440 |
Reaction
Chain : | A, C | ||||||||
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UniProt : | P81947 (TBA1B_BOVIN) | ||||||||
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Chain : | B, D |
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UniProt : | Q6B856 (TBB2B_BOVIN) |
Reaction : | - |
Chain : | E |
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UniProt : | P63043 (STMN4_RAT) |
Reaction : | - |
Chain : | F |
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UniProt : | E1BQ43 |
Reaction : | - |