Brand  (β version)

PDB ID: 5M7F

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Ligands
Code Name Style Show Link
DPM 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1h-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5M7F   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Human porphobilinogen deaminase in complex with DPM cofactor
Release Data : 2017-11-15
Compound :
mol_id molecule chains synonym
1 Porphobilinogen deaminase A,B PBG-D,Hydroxymethylbilane synthase,HMBS,Pre-uroporphyrinogen synthase
ec: 2.5.1.61
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HMBS, PBGD, UPS
Authors : Pluta, P., Millet, O., Roversi, P., Rojas, A.L., Gu, S.
Keywords : Porphobilinogen deaminase, heme biosynthesis, porphyria, HMBS, transferase
Exp. method : X-RAY DIFFRACTION ( 2.78 Å )
Citation :

Structural basis of pyrrole polymerization in human porphobilinogen deaminase.

Pluta, P.,Roversi, P.,Bernardo-Seisdedos, G.  et al.
(2018)  Biochim Biophys Acta Gen Subj  1862 : 1948 - 1955

PubMed: 29908816
DOI: 10.1016/j.bbagen.2018.06.013

Reaction

Chain : A, B
UniProt : P08397 (HEM3_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+) 2.5.1.61 PubMed:18004775, PubMed:18936296, PubMed:19138865, PubMed:23815679
left-to-right PubMed:19138865