Brand  (β version)

PDB ID: 5LS7

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Ligands
Code Name Style Show Link
74C Methyl radical PoSSuM
ACO Acetyl coenzyme *a PoSSuM
CO2 Carbon dioxide PoSSuM
GOL Glycerol PoSSuM
MG Magnesium ion PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
SCN Thiocyanate ion PoSSuM
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
PVO 2,2-bis(oxidanyl)propanoic acid
Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 5LS7   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Complex of wild type E. coli alpha aspartate decarboxylase with its processing factor PanZ
Release Data : 2017-09-13
Compound :
mol_id molecule chains synonym
1 Aspartate 1-decarboxylase A Aspartate alpha-decarboxylase
ec: 4.1.1.11
other_details: Residues 1-17 are the purification tag.
mol_id molecule chains
2 PanD maturation factor B
other_details: The C-terminus is not visible in the electron density
mol_id molecule chains synonym
3 Aspartate 1-decarboxylase D Aspartate alpha-decarboxylase
ec: 4.1.1.11
other_details: The N-terminal residue is a pyruvoyl moiety formed after post-translation backbone cleavage after protein folding. Cysteine 78 is oxidised.
Source :
mol_id organism_scientific expression_system
1 Escherichia coli K-12  (taxid:83333) Escherichia coli  (taxid:562)
gene: panD, b0131, JW0127
mol_id organism_scientific expression_system
2 Escherichia coli K-12  (taxid:83333) Escherichia coli  (taxid:562)
gene: panM, panZ, yhhK, b3459, JW3424
mol_id organism_scientific expression_system
3 Escherichia coli K-12  (taxid:83333) Escherichia coli  (taxid:562)
gene: panD, b0131, JW0127
Authors : Monteiro, D.C.F., Webb, M.E., Pearson, A.R.
Keywords : protein derived cofactor, coenzyme A biosynthesis, protein complex, metabolic pathway regulation, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.16 Å )
Citation :

The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD-PanZAcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N-Pentyl Pantothenamide (N5-Pan).

Arnott, Z.L.P.,Nozaki, S.,Monteiro, D.C.F.  et al.
(2017)  Biochemistry  56 : 4931 - 4939

PubMed: 28832133
DOI: 10.1021/acs.biochem.7b00509

Reaction

Chain : D
UniProt : P0A790 (PAND_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + L-aspartate = beta-alanine + CO2 4.1.1.11 PubMed:6767707
-
Chain : B
UniProt : P37613 (PANZ_ECOLI)
Reaction : -