Het-PDB Navi2 (PDB: 5KM4)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name		Style	Show	Link
IU	5-iodouridine-5'-monophosphate				PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 5KM4

Code :

5KM4 PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-5-Iodo-UMP complex

Release Data :

2017-06-28

Compound :

mol_id	molecule	chains	synonym
1	Histidine triad nucleotide-binding protein 1	A,B	Adenosine 5'-monophosphoramidase
	ec: 3.-.-.-

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: HINT1, HINT expression_system_strain: Rosetta 2 pLysS expression_system_vector_type: plasmid expression_system_plasmid: pMCSG7

Authors :

Maize, K.M., Finzel, B.C.

Keywords :

HINT, histidine triad, HIT, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 1.4000 Å )

Citation :

A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.

Maize, K.M.,Shah, R.,Strom, A. et al.
(2017) Mol. Pharm. 14 : 3987 - 3997

Chain :

A, B

UniProt :

P49773 (HINT1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)	-	PubMed:15703176, PubMed:16835243, PubMed:17217311, PubMed:17337452, PubMed:22329685, PubMed:23614568, PubMed:28691797, PubMed:29787766, PubMed:31990367
adenosine 5'-phosphoramidate + H2O = AMP + NH4(+)	-

PDB ID: 5KM4