Brand  (β version)

PDB ID: 5K0S

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Ligands
Code Name Style Show Link
0OU 2-({3-[(3,5-dichlorobenzyl)amino]propyl}amino)quinolin-4(1h)-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5K0S   PDBj   RCSB PDB   PDBe
Header : ligase/ligase inhibitor
Title : Crystal structure of methionyl-tRNA synthetase MetRS from Brucella melitensis in complex with inhibitor Chem 1312
Release Data : 2016-05-25
Compound :
mol_id molecule chains synonym
1 Methionine--tRNA ligase A,B,C Methionyl-tRNA synthetase,MetRS
ec: 6.1.1.10
fragment: BrabA.10201.a.A1
Source :
mol_id organism_scientific expression_system
1 Brucella suis biovar 1 (strain 1330)  (taxid:204722) Escherichia coli  (taxid:469008)
strain: 1330
gene: metG, BR0995, BS1330_I0991
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: BrabA.10201.a.A1metG
Authors : Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Keywords : SSGCID, MetRS, methionyl-tRNA synthetase, protein biosynthesis, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, LIGASE, ligase-ligase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.4500 Å )
Citation :

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo, K.K.,Ranade, R.M.,Zhang, Z.  et al.
(2016)  Plos One  11 : e0160350 - e0160350

PubMed: 27500735
DOI: 10.1371/journal.pone.0160350

Reaction

Chain : A, B, C
UniProt : P59078 (SYM_BRUSU)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L- methionyl-tRNA(Met) 6.1.1.10 HAMAP- Rule:MF_01228
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