Brand  (β version)

PDB ID: 5IWG

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
CA Calcium ion PoSSuM
IWX N-(4-amino-4'-fluoro[1,1'-biphenyl]-3-yl)oxane-4-carboxamide PoSSuM
PG5 1-methoxy-2-[2-(2-methoxy-ethoxy]-ethane PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
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Structure summary

Code : 5IWG   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : HDAC2 WITH LIGAND BRD4884
Release Data : 2016-08-31
Compound :
mol_id molecule chains synonym
1 Histone deacetylase 2 A,B,C HD2
ec: 3.5.1.98
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HDAC2
Authors : Steinbacher, S.
Keywords : HDAC HISTONE DEACETYLASE, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.66 Å )
Citation :

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

Wagner, F.F.,Weiwer, M.,Steinbacher, S.  et al.
(2016)  Bioorg.Med.Chem.  24 : 4008 - 4015

PubMed: 27377864
DOI: 10.1016/j.bmc.2016.06.040

Reaction

Chain : A, B, C
UniProt : Q92769 (HDAC2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl- [histone] 3.5.1.98 PubMed:28497810
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H2O + N(6)-acetyl-L-lysyl-[protein] = acetate + L-lysyl- [protein] - PubMed:19343227
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H2O + N(6)-(2E)-butenoyl-L-lysyl-[protein] = (2E)-2-butenoate + L-lysyl-[protein] - PubMed:28497810
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H2O + N(6)-(2-hydroxyisobutanoyl)-L-lysyl-[protein] = 2- hydroxy-2-methylpropanoate + L-lysyl-[protein] - PubMed:29192674
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