Het-PDB Navi2 (PDB: 5IMX)

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Ligands
Code	Name		Style	Show	Link
CZ4	5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1h-pyrazol-4-yl}pyrimidine-2,4-diamine				PoSSuM

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Download interaction data: 5IMX

Code :

5IMX PDBj RCSB PDB PDBe

Header :

TRANSFERASE/TRANSFERASE INHIBITOR

Title :

Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine

Release Data :

2016-05-04

Compound :

mol_id	molecule	chains	synonym
1	ALK tyrosine kinase receptor	A	Anaplastic lymphoma kinase
	ec: 2.7.10.1 fragment: UNP RESIDUES 1093-1411

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:469008)
	gene: ALK expression_system_strain: BL21(DE3)

Authors :

Wang, C., Zhang, P., Dong, J.

Keywords :

Kinase, inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex

Exp. method :

X-RAY DIFFRACTION ( 2.1200 Å )

Citation :

Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.

Zhang, P.,Dong, J.,Zhong, B. et al.
(2016) Bioorg.Med.Chem.Lett. 26 : 1910 - 1918

Chain :

UniProt :

Q9UM73 (ALK_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein]	2.7.10.1	PROSITE-ProRule:PRU10028, PubMed:30061385, PubMed:34819673
	-	PROSITE-ProRule:PRU10028, PubMed:30061385, PubMed:34819673

PDB ID: 5IMX