Het-PDB Navi2 (PDB: 5IGJ)

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Ligands
Code	Name	Link
GMP	Guanosine	PoSSuM
CTY	Clarithromycin	PoSSuM
IPA	Isopropyl alcohol	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5IGJ

Code :

5IGJ PDBj RCSB PDB PDBe

Header :

TRANSFERASE/ANTIBIOTIC

Title :

Macrolide 2'-phosphotransferase type I - complex with guanosine and clarithromycin

Release Data :

2017-04-26

Compound :

mol_id	molecule	chains	synonym
1	Macrolide 2'-phosphotransferase	A	Macrolide 2'-phosphotransferase I,Macrolide 2'-phosphotransferase I Mph(A),Macrolide 2'-phosphotransferase Mph(A),Macrolide 2-phosphotransferase,Macrolide 2-phosphotransferase protein,macrolide resistance protein,Macrolide-phosphotransferase,mph(A),Mph(A),Mph(A) macrolide 2'-phosphotransferase I,Uncharacterized protein

Source :

mol_id	organism_scientific	expression_system
1	Escherichia coli (taxid:562)	Escherichia coli (taxid:469008)
	strain: Tf481A gene: mphA, mph(A), mph2, AM267_25240, AM268_24740, AN205_25580, AN669_16770, ASU34_20250, AZ95_0038, ECONIH1_26770, ERS085366_04054, ERS085367_04848, ERS139269_04809, ERS150873_04753, ETN48_p0083, orf00017, pCTXM123_C0996_11, pKC394-009, SK74_04859, SK86_03516, UN86_19875 expression_system_strain: BL21(DE3) expression_system_vector_type: plasmid

Authors :

Berghuis, A.M., Fong, D.H.

Keywords :

macrolide phosphotransferase, kinase, TRANSFERASE-ANTIBIOTIC complex

Exp. method :

X-RAY DIFFRACTION ( 1.4000 Å )

Citation :

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.

Fong, D.H.,Burk, D.L.,Blanchet, J. et al.
(2017) Structure 25 : 750 - 761.e5

PDB ID: 5IGJ