Het-PDB Navi2 (PDB: 5GHZ)

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Ligands
Code	Name		Style	Show	Link
CED	5-methyl-2-[2-oxo-1-(2-thiophen-2-yl-acetylamino)-ethyl]-3,6-dihydro-2h-[1,3]thiazine-4-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 5GHZ

Code :

5GHZ PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of beta-lactamase PenP mutant-E166H in complex with cephaloridine as "pre-deacylation" intermediate

Release Data :

2017-01-25

Compound :

mol_id	molecule	chains	synonym
1	Beta-lactamase	B,A	Penicillinase
	ec: 3.5.2.6 fragment: UNP residues 43-307 mutation: E166H

Source :

mol_id	organism_scientific	expression_system
1	Bacillus licheniformis (taxid:1402)	Escherichia coli (taxid:562)
	gene: penP, blaP expression_system_vector_type: plasmid

Authors :

Pan, X., Zhao, Y.

Keywords :

hydrolase

Exp. method :

X-RAY DIFFRACTION ( 1.9300 Å )

Citation :

Crystallographic Snapshots of Class A beta-Lactamase Catalysis Reveal Structural Changes That Facilitate beta-Lactam Hydrolysis

Pan, X.,He, Y.,Lei, J. et al.
(2017) J. Biol. Chem. 292 : 4022 - 4033

Chain :

B, A

UniProt :

P00808 (BLAC_BACLI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
a beta-lactam + H2O = a substituted beta-amino acid	3.5.2.6	PROSITE- ProRule:PRU10101
a beta-lactam + H2O = a substituted beta-amino acid	-	PROSITE- ProRule:PRU10101

PDB ID: 5GHZ