Brand  (β version)

PDB ID: 5G3S

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
FDA Dihydroflavine-adenine dinucleotide PoSSuM
HG Mercury (II) ion PoSSuM
NO3 Nitrate ion PoSSuM
SM Samarium (III) ion PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
Non-standard Residues
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CSS S-mercaptocysteine
Glycosylation
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Structure summary

Code : 5G3S   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The structure of the L-tryptophan oxidase VioA from Chromobacterium violaceum - Samarium derivative
Release Data : 2016-08-03
Compound :
mol_id molecule chains
1 L-TRYPTOPHAN OXIDASE VIOA A,B
ec: 1.4.3.23
mutation: YES
Source :
mol_id organism_scientific expression_system
1 CHROMOBACTERIUM VIOLACEUM  (taxid:536) ESCHERICHIA COLI  (taxid:469008)
strain: 12472
expression_system_strain: BL21(DE3)
expression_system_variant: LAMBDA
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX
Authors : Krausze, J., Rabe, J., Moser, J.
Keywords : OXIDOREDUCTASE, VIOLACEIN, L-TRYPTOPHAN OXIDASE, FLAVOENZYME, SAMARIUM DERIVATIVE
Exp. method : X-RAY DIFFRACTION ( 2.076 Å )
Citation :

Biosynthesis of Violacein: Structure and Function of L-Tryptophan Oxidase Vioa Chromobacterium Violaceum

Fuller, J.,Roepke, R.,Krausze, J.  et al.
(2016)  J.Biol.Chem.  291 : 20068

PubMed: 27466367
DOI: 10.1074/JBC.M116.741561

Reaction

Chain : A, B
UniProt : Q9S3V1 (VIOA_CHRVO)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + O2 = 2-iminio-3-(indol-3-yl)propanoate + H2O2 1.4.3.23 PubMed:27466367
-
7-chloro-L-tryptophan + O2 = 3-(7-chloroindol-3-yl)-2- iminopropanoate + H2O2 1.4.3.23 PubMed:27466367
-
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:27466367
Binds 1 FAD per subunit.
Mg(2+) ECO:0000269 | PubMed:27466367
Binds 1 Mg(2+) ion per subunit.