Brand  (β version)

PDB ID: 5FN0

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Ligands
Code Name Style Show Link
FAD Flavin-adenine dinucleotide PoSSuM
JHY 3-(5,6-dichloro-2-oxobenzo[D]oxazol-3(2h)-yl)propanoic acid PoSSuM
Non-standard Residues
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Structure summary

Code : 5FN0   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180
Release Data : 2016-01-13
Compound :
mol_id molecule chains synonym
1 KYNURENINE 3-MONOOXYGENASE A,B,C,D PFKMO, KYNURENINE 3-HYDROXYLASE
ec: 1.14.13.9
mutation: YES
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS FLUORESCENS  (taxid:294) ESCHERICHIA COLI  (taxid:562)
Authors : Mole, D.J., Webster, S.P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J.P., Mirguet, O., Walker, A., Beaufils, B., Ancellin, N., Trottet, L., Beneton, V., Mowat, C.G., Wilkinson, M., Rowland, P., Haslam, C., McBride, A., Homer, N.Z.M., Baily, J.E., Sharp, M.G.F., Garden, O.J., Hughes, J., Howie, S.E.M., Holmes, D., Liddle, J., Iredale, J.P.
Keywords : OXIDOREDUCTASE, KMO
Exp. method : X-RAY DIFFRACTION ( 3.19 Å )
Citation :

Kynurenine-3-Monooxygenase Inhibition Prevents Multiple Organ Failure in Rodent Models of Acute Pancreatitis.

Mole, D.J.,Webster, S.P.,Uings, I.  et al.
(2016)  Nat.Med. (N.Y.)  22 : 202

PubMed: 26752518
DOI: 10.1038/NM.4020

Reaction

Chain : A, B, C, D
UniProt : Q84HF5 (KMO_PSEFL)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + H2O + NADP(+) 1.14.13.9 HAMAP-Rule:MF_01971, PubMed:16973376, PubMed:28604669, PubMed:29429898
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