Brand  (β version)

PDB ID: 5FAW

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Ligands
Code Name Style Show Link
CHT Choline ion PoSSuM
MLI Malonate ion PoSSuM
NA Sodium ion PoSSuM
Non-standard Residues
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Glycosylation
Code Name Emphasize
Modification
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Structure summary

Code : 5FAW   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : T502A mutant of choline TMA-lyase
Release Data : 2016-09-28
Compound :
mol_id molecule chains
1 Choline trimethylamine-lyase A,B
ec: 4.3.99.4
mutation: T502A
Source :
mol_id organism_scientific expression_system
1 Desulfovibrio alaskensis  (taxid:207559) Escherichia coli BL21(DE3)  (taxid:469008)
strain: G20
gene: Dde_3282
Authors : Funk, M.A., Drennan, C.L.
Keywords : mutant, radical, lyase
Exp. method : X-RAY DIFFRACTION ( 1.852 Å )
Citation :

Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.

Bodea, S.,Funk, M.A.,Balskus, E.P.  et al.
(2016)  Cell Chem Biol  23 : 1206 - 1216

PubMed: 27642068
DOI: 10.1016/j.chembiol.2016.07.020

Reaction

Chain : A, B
UniProt : Q30W70 (CUTC_OLEA2)
Reaction: EC: Evidence:
Physiological Direction:
choline = acetaldehyde + trimethylamine 4.3.99.4 HAMAP-Rule:MF_02058, PubMed:23151509
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