Brand  (β version)

PDB ID: 5F02

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Ligands
Code Name Style Show Link
5T9 (2~{S},4~{R})-4-[(2-chloranyl-4-methoxy-phenyl)-bis(oxidanyl)-$L^{4}-sulfanyl]-1-[3-(5-chloranylpyridin-2-yl)azetidin-3-yl]carbonyl-~{N}-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide PoSSuM
GOL Glycerol PoSSuM
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Structure summary

Code : 5F02   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CATHEPSIN L IN COMPLEX WITH (2S,4R)-4-(2-Chloro-4-methoxy-benzenesulfonyl)-1-[3-(5-chloro-pyridin-2-yl)-azetidine-3-carbonyl]-pyrrolidine-2-carboxylic acid (1-cyano-cyclopropyl)-amide
Release Data : 2016-02-24
Compound :
mol_id molecule chains synonym
1 Cathepsin L1 A Cathepsin L,Major excreted protein,MEP
ec: 3.4.22.15
fragment: CATALYTIC DOMAIN, RESIDUES 114-333
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: CTSL, CTSL1
Authors : Banner, D., Benz, J., Stihle, M., Kuglstatter, A.
Keywords : PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.43 Å )
Citation :

A Real-World Perspective on Molecular Design.

Kuhn, B.,Guba, W.,Hert, J.  et al.
(2016)  J.Med.Chem.  59 : 4087 - 4102

PubMed: 26878596
DOI: 10.1021/acs.jmedchem.5b01875

Reaction

Chain : A
UniProt : P07711 (CATL1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl- dipeptidase activity. 3.4.22.15 PubMed:9468501
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