Brand  (β version)

PDB ID: 5EY9

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Ligands
Code Name Style Show Link
5SV [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl icosyl hydrogen phosphate PoSSuM
GOL Glycerol PoSSuM
Non-standard Residues
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Structure summary

Code : 5EY9   PDBj   RCSB PDB   PDBe
Header : LIGASE
Title : Structure of FadD32 from Mycobacterium marinum complexed to AMPC12
Release Data : 2015-12-16
Compound :
mol_id molecule chains synonym
1 Long-chain-fatty-acid--AMP ligase FadD32 A,B FAAL,Acyl-AMP synthetase
ec: 6.2.1.-
Source :
mol_id organism_scientific expression_system
1 Mycobacterium marinum  (taxid:1781) Escherichia coli  (taxid:562)
gene: fadD32, MMAR_5365
Authors : Guillet, V., Maveyraud, L., Mourey, L.
Keywords : Ligase, fatty-acyl AMP ligase
Exp. method : X-RAY DIFFRACTION ( 2.500 Å )
Citation :

Insight into Structure-Function Relationships and Inhibition of the Fatty Acyl-AMP Ligase (FadD32) Orthologs from Mycobacteria.

Guillet, V.,Galandrin, S.,Maveyraud, L.  et al.
(2016)  J.Biol.Chem.  291 : 7973 - 7989

PubMed: 26900152
DOI: 10.1074/jbc.M115.712612

Reaction

Chain : A, B
UniProt : B2HMK0 (FAA32_MYCMM)
Reaction: EC: Evidence:
Physiological Direction:
a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate 6.2.1.20 UniProtKB:O53580
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ATP + dodecanoate + H(+) = diphosphate + dodecanoyl-AMP - PubMed:26900152
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ATP + H(+) + tetradecanoate = diphosphate + tetradecanoyl-AMP - PubMed:26900152
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