Brand  (β version)

PDB ID: 5EWA

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
9BZ (3~{R},5~{R},7~{a}~{S})-2,2-dimethyl-5-(sulfanylmethyl)-3,5,7,7~{a}-tetrahydro-[1,3]thiazolo[4,3-B][1,3]thiazole-3-carboxylic acid PoSSuM
EDO 1,2-ethanediol PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 5EWA   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26
Release Data : 2016-06-01
Compound :
mol_id molecule chains synonym
1 Beta-lactamase IMP-1 A,B,C,D BLAIMP,Beta-lactamase type II,Penicillinase. Metallo-beta-lactamase class B1 IMP-1
ec: 3.5.2.6
Source :
mol_id organism_scientific expression_system
1 Serratia marcescens  (taxid:615) Escherichia coli BL21(DE3)  (taxid:469008)
expression_system_variant: solu
expression_system_vector_type: plasmid
expression_system_plasmid: pOPIN-F
Authors : Kosmopoulou, M., Hinchliffe, P., Spencer, J.
Keywords : inhibitor, carbapenemase, antibiotic resistance, hydrolase
Exp. method : X-RAY DIFFRACTION ( 2.300 Å )
Citation :

Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.

Hinchliffe, P.,Gonzalez, M.M.,Mojica, M.F.  et al.
(2016)  Proc.Natl.Acad.Sci.USA  113 : E3745 - E3754

PubMed: 27303030
DOI: 10.1073/pnas.1601368113

Reaction

Chain : A, B, C, D
UniProt : P52699 (BLAB_SERMA)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PubMed:8141584
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