Brand  (β version)

PDB ID: 5ETL

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
ATP Adenosine-5'-triphosphate PoSSuM
5RV 2-[(2-azanyl-6-oxidanylidene-3,9-dihydropurin-8-yl)sulfanylmethyl]benzenecarbonitrile PoSSuM
Non-standard Residues
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Structure summary

Code : 5ETL   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE/TRANSFERASE inhibitor
Title : E. coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.82 angstrom resolution
Release Data : 2016-05-04
Compound :
mol_id molecule chains synonym
1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase A,B,C,D 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase,PPPK,7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase,HPPK
ec: 2.7.6.3
other_details: Loop 3 residues 86-91 left unmodelled due to poor density.
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
gene: folK, b0142, JW0138
Authors : Dennis, M.L., Peat, T.S., Swarbrick, J.D.
Keywords : inhibitor, complex, ampcpp, pyrophosphokinase, TRANSFERASE-TRANSFERASE inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 1.82 Å )
Citation :

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.

Dennis, M.L.,Pitcher, N.P.,Lee, M.D.  et al.
(2016)  J.Med.Chem.  59 : 5248 - 5263

PubMed: 27094768
DOI: 10.1021/acs.jmedchem.6b00002

Reaction

Chain : A, B, C, D
UniProt : P26281 (HPPK_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin- 6-yl)methyl diphosphate + AMP + H(+) 2.7.6.3 PubMed:1325970
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