Het-PDB Navi2 (PDB: 5EBZ)

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Ligands
Code	Name		Link
5TL	2-azanyl-5-phenyl-3-(4-sulfamoylphenyl)benzamide		PoSSuM
5LS	2,4-di-O-sulfo-alpha-D-glucopyranose		PoSSuM
GLC	Alpha-D-glucopyranose		PoSSuM
PDX	2,3-di-O-sulfo-alpha-D-glucopyranose		PoSSuM
5TJ	[(2r,3r,4r,5r,6s)-2-(hydroxymethyl)-5,6-bis(oxidanyl)-3-oxidanylsulfanyloxy-oxan-4-yl] hydrogen sulfate		PoSSuM
5TM	[(2s,3r,4s,5r,6r)-6-(hydroxymethyl)-2,5-bis(oxidanyl)-4-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate		PoSSuM
Z4K	2-O-sulfo-alpha-D-glucopyranose		PoSSuM
5TK	(2s,3r,4r,5s,6r)-6-(hydroxymethyl)-5-oxidanylsulfanyloxy-oxane-2,3,4-triol		PoSSuM
5TH	[(2s,3r,4s,5s,6r)-6-(hydroxymethyl)-2,4-bis(oxidanyl)-5-oxidanylsulfanyloxy-oxan-3-yl] hydrogen sulfate		PoSSuM
		: Polysaccharide

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Download interaction data: 5EBZ

Code :

5EBZ PDBj RCSB PDB PDBe

Header :

Transferase/transferase inhibitor

Title :

Crystal structure of human IKK1

Release Data :

2016-11-02

Compound :

mol_id	molecule	chains	synonym
1	Inhibitor of nuclear factor kappa-B kinase subunit alpha	A,B,C,D,E,F,G,H,I,J,K,L	IkappaB kinase,Conserved helix-loop-helix ubiquitous kinase,I-kappa-B kinase 1,IKK1,Nuclear factor NF-kappa-B inhibitor kinase alpha,NFKBIKA,Transcription factor 16,TCF-16
	ec: 2.7.11.10 mutation: S176E, S180E

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Spodoptera frugiperda (taxid:7108)
	gene: CHUK, IKKA, TCF16

Authors :

Polley, S., Passos, D., Huang, D., Biswas, T., Verma, I., Lyumkis, D., Ghosh, G.

Keywords :

kinase, inhibitor, Transferase-transferase inhibitor complex

Exp. method :

X-RAY DIFFRACTION ( 4.50 Å )

Citation :

Structural Basis for the Activation of IKK1/ alpha.

Polley, S.,Passos, D.O.,Huang, D.B. et al.
(2016) Cell Rep 17 : 1907 - 1914

PDB ID: 5EBZ