Brand  (β version)

color scheme of protein:

hetatm:
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Ligands
Code Name Link
5TW 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA
Code : 5CXI
Header : TRANSCRIPTION
Title : Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)
Release Data : 2016-02-17
Compound :
mol_id molecule chains
1 HTH-type transcriptional repressor KstR A,B
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: kstR, Rv3574
expression_system_strain: BL21 (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET30a
Authors : Ho, N.A.T., Dawes, S., Kendall, S., Casabon, I., Crowe, A.M., Baker, E.N., Eltis, L.D., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Keywords : Transcriptional repressor, TetR family Tcholesterol catabolism, CoA thioester ligand, Structural Genomics, TB Structural Genomics Consortium, TBSGC, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Ho, N.A.,Dawes, S.S.,Crowe, A.M.  et al.
(2016)  J.Biol.Chem.  291 : 7256 - 7266

PubMed: 26858250
DOI: 10.1074/jbc.M115.707760

Chain : A, B
UniProt : P96856 (KSTR_MYCTU)
Reaction : -