Brand  (β version)

PDB ID: 5CXI

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
5TW 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 5CXI   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal structure of Mycobacterium tuberculosis KstR in complex with 3-oxo-23,24-bisnorchol-4-en-22-oyl-CoA (4-BNC-CoA)
Release Data : 2016-02-17
Compound :
mol_id molecule chains
1 HTH-type transcriptional repressor KstR A,B
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli  (taxid:469008)
strain: ATCC 25618 / H37Rv
gene: kstR, Rv3574
expression_system_strain: BL21 (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pET30a
Authors : Ho, N.A.T., Dawes, S., Kendall, S., Casabon, I., Crowe, A.M., Baker, E.N., Eltis, L.D., Lott, J.S., TB Structural Genomics Consortium (TBSGC)
Keywords : Transcriptional repressor, TetR family Tcholesterol catabolism, CoA thioester ligand, Structural Genomics, TB Structural Genomics Consortium, TBSGC, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

Ho, N.A.,Dawes, S.S.,Crowe, A.M.  et al.
(2016)  J.Biol.Chem.  291 : 7256 - 7266

PubMed: 26858250
DOI: 10.1074/jbc.M115.707760

Reaction

Chain : A, B
UniProt : P96856 (KSTR_MYCTU)
Reaction : -